Doxepin Has a Potent and Long-Acting Spinal Anesthetic Effect in Rats
نویسندگان
چکیده
منابع مشابه
بررسی تاًثیرتزریق اینتراتکال آمی تریپتیلین ودوکسپین در ایجاد بیحسی نخاعی و مقایسه آن با بوپیواکائین
Background and aimsNowadays tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms involving Sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenua...
متن کاملevaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
conclusions it seems that tertiary amine drugs such as amitriptyline and doxepin had reasonable potencies of spinal blockade when compared to bupivacaine. however, amitriptyline had a more potent and long-acting spinal anesthetic effect. amitriptyline may turn out to be a clinically valuable local anesthetic. results in groups 1 and 2, a total of 3 rats died. after adjusting the concentrations,...
متن کاملEvaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
BACKGROUND Tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms, including sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and the...
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Wnt signaling pathways are required for a wide variety of biological processes ranging from embryonic development to tissue repair and regeneration. Dickkopf-2 (DKK2) is classically defined as a canonical Wnt inhibitor, though it may play a role in activating non-canonical Wnt pathways in the context of endothelial network formation after acute injury. Here we report the discovery of a fusion p...
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در طی چند دهه ی اخیر، مفهوم «تراژدی» و «قهرمان تراژدی» توجهی روزافرون را تقریباً در تمام حوزه های نقد ادبی به خود معطوف کرده است. برخی نظیر ارسطو، نیچه، و آرتور میلر به بازخوانی آن پرداخته و برخی دیگر نظیر سارتر، استریندبرگ، یوجین اُنیل، برتولت برشت، و آنتونین آرتود به افزودن ابعاد نوینی به این مبحث همت گماشته اند. آنچه قهرمان تراژدی مدرن را از مفهوم کلاسیک آن متمایز می کند نه لغزش تراژیک متداول ...
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ژورنال
عنوان ژورنال: The Kaohsiung Journal of Medical Sciences
سال: 2006
ISSN: 1607-551X
DOI: 10.1016/s1607-551x(09)70223-2